Southern Illinois Associates LLC

Esketamine Therapy

 We are certified SPRAVATO® treatment center

What is SPRAVATO?.

 it  is a prescription medicine, used along with an antidepressant taken by mouth, for treatment-resistant depression (TRD) in adults. 

First Nasal Spray for Depression

SPRAVATO is the first nasal spray medication, taken along with an oral antidepressant, for adults with treatment-resistant depression (TRD).

If you’ve struggled with depression and tried two or more antidepressants* in your current episode without adequate relief, talk to your healthcare provider to see if you have treatment-resistant depression.

*Of adequate dose and duration.

How Can I Get Spravato?

Indication For Spravato/Esketamine


• Treatment-resistant depression (TRD) in adults. 
• Depressive symptoms in adults with major depressive disorder (MDD) with
acute suicidal ideation or behavior.  

What to Expect During Your SPRAVATO® Treatment

Getting Started with SPRAVATO
  • Review your overall medical and depression treatment history. Be sure to tell u s if you have a history of abusing prescription or street drugs or a problem with alcohol
  •  Ask if adding SPRAVATO® to your overall treatment plan might be a next step for you
  •  You should not expect treatment on your first visit. A healthcare provider at the certified SPRAVATO® treatment center will do their own assessment to determine if SPRAVATO® may be right for you

if you have had medical conditions such as

  • blood vessel disease (aneurysm),
  • an abnormal connection between your blood vessels (arteriovenous malformation),
  • a history of bleeding in the brain or
  • If you are allergic to esketamine, ketamine or any of the ingredients in SPRAVATOngs.
Treatment Days
  • You’ll need to plan for rides to and from our clinic
  • You will not be able to drive, operate machinery or do anything where you need to be completely alert until the day after a treatment session, following a restful sleep.
  • You may want to bring a book, a relaxing playlist or another form of entertainment for the session because we will monitor you for at least two hours after treatment.
  • Avoid eating two hours before and drinking liquids 30 minutes before taking SPRAVATO
  • f you take a nasal corticosteroid or nasal decongestant medicine, take these medicines at least one hour before taking SPRAVATO
How to Use SPRAVATO Nasal Spray

You will administer SPRAVATO® yourself under the supervision of a healthcare provider, who will show you how to use the SPRAVATO  nasal spray device.

Learn More About Using SPRAVATO® Nasal Spray

SPRAVATO® Side Effects

There’s an increased risk of suicidal thoughts and behavior with SPRAVATO

The most common side effects that can occur during and after taking SPRAVATO® include:

  • Dissociation (feeling disconnected from yourself, your thoughts, feelings, space and time)
  • Dizziness
  • Nausea
  • Sedation (sleepiness)
  • Spinning sensation
  • Reduced sense of touch and sensation
  • Anxiety
  • Lack of energy
  • Increased blood pressure
  • Vomiting
  • Feeling drunk
Staying on SPRAVATO

You’ll take SPRAVATO® twice a week for the first month. During the second month, you’ll take it once a week. After that, you’ll take it once a week or once every two weeks. You’ll continue to take an oral antidepressant as prescribed.

Get In Touch

Patient portal




16 Junction Drive W, Ste 2,

Glen Carbon, IL 62034


Mon – Fri: 8:30 Am to 5 PM

2nd Saturday of every month:

From: 8:30 AM to 2 PM